PRECIGEN EXEMPLAR

Enabling discovery to improve clinical success

ENABLING DISCOVERY

Founded in 2008, Precigen Exemplar enables discovery by providing the vehicle to break new ground on the medical research frontier. We develop specialized miniature swine models that are genetically engineered to exhibit a wide variety of human disease states and to provide a more accurate platform to test the efficacy of new medications and devices.

All too often, researchers have lacked animal models that faithfully represent human diseases. As a result, a sizeable barrier has blocked progress in the discovery of human disease mechanisms; prevention strategies and therapeutics, novel diagnostics, procedures, devices; and the ability to predict in humans the efficacy of those next-generation therapeutics, procedures, and devices.

Each Precigen Exemplar facility is accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC). Our employees are active members of the American Association of Laboratory Animal Science, which is dedicated to the humane care and treatment of laboratory animals, and we also comply with the letter and spirit of the Animal Welfare Act.

Precigen Exemplar is a subsidiary of Precigen.

gene targeting/editing and somatic cell nuclear transfer services
Standard Models
Custom Models
Non-GLP Clinical Research

“The porcine disease models we are developing at Precigen Exemplar bridge the substantial gap between the rodents typically used in preclinical testing and the patients in clinical trials. Having a model that more closely replicates a specific human disease provides better predictive efficacy, which results in faster, more efficient therapeutic development.”

Christopher Rogers, PhD
CEO and CSO of Precigen Exemplar

Our Approach

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Precigen Exemplar is advancing a broad pipeline of proprietary genetically engineered ExeGen® MiniSwine models that are invaluable for disease mechanism discovery and preclinical efficacy testing.

Miniature Swine for the Biomedical Market
The Yucatan MiniSwine is the accepted standard and ideal model for the biomedical and medical device fields. MiniSwine research models are designed to provide improved predictive power to the preclinical stages of therapeutic development.

Precigen Exemplar is a leader in providing MiniSwine for research in human diseases. Our models have a wide range of applications ultimately enabling discovery.

Learn more about our models and how they’re being applied to medical research.

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Animal Welfare

We are committed to the humane use and care of each research animal. Our first priority is animal welfare, and we have rigorous standards to ensure that we meet or exceed all requirements for care though a robust program of care and established veterinary protocols. Each one of our facilities is PHS assured, FDA compliant and USDA approved.

We believe our work will enable discovery of life saving drugs, devices and therapies and every employee of Precigen Exemplar believes each animal deserves the greatest respect and care – and that’s exactly what we deliver every day.

Animal Welfare Concerns? Please Let Us Know.

Our Platform Advantages

Benefits of Miniature Swine Models
Our ExeGen® Yucatan miniature pig models offer a more accurate and effective testing platform for new treatments than traditional mouse models.

Advantages of Miniature Swine Over Traditional Models:

  • Human-like disease phenotypes on accelerated timelines
  • Human-like size useful for device and imaging work
  • Anatomically similar to humans (e.g., similar structure of cardiovascular systems)
  • Improved translational value to human clinical trials

Challenges of Medical Product Development
The process to develop successful treatments can be costly and for rare disease states, limited patient populations make predictive efficacy much more difficult.

MiniSwine models aim to address these challenges and improve the outcomes, enabling significant cost savings in development and the ability to bring medications to market faster.

Pipeline

Precigen Exemplar is providing miniature swine models to enable research in human diseases.

Precigen Exemplar Pipeline

As of May 5, 2020
ModelIndicationGene TargetingFoundersCharacterizationAvailable in Portfolio
ExeGen LDLR -/- & +/-Heart Disease
ExeGen CFTR-/-Cystic Fibrosis
ExeGen CFTRF508del/F508delCystic Fibrosis
ExeGen SCN5A+/E558XCardiac Arrhythmia
ExeGen TP53+/R167H, R167/R167HCancer
ExeGen TP53+/R167H & KRAS+G12DCancer
ExeGen DMD+/ex52delNeuromuscular
ExeGen ATM-/-Neurodegeneration
ExeGen CLN3ex7&8del/ex7&8delNeurodegeneration
ExeGen HTT+/Ex1+(CAG)85Neurodegeneration
ExeGen MYH7+/R403QHypertrophic Cardiomyopathy
ExeGen NF1+/ex42delNervous System
ExeGen PKD1+/-Renal Disease
ExeGen SCDhHBA/hHBA/hHBG-hHBBS/ hHBG-hHBBSBlood Disorders
Exemplar Careers

Interested in joining our team?

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Questions?

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