Enabling discovery to improve clinical success
Founded in 2008, Precigen Exemplar enables discovery by providing the vehicle to break new ground on the medical research frontier. We develop specialized miniature swine models that are genetically engineered to exhibit a wide variety of human disease states and to provide a more accurate platform to test the efficacy of new medications and devices.
All too often, researchers have lacked animal models that faithfully represent human diseases. As a result, a sizeable barrier has blocked progress in the discovery of human disease mechanisms; prevention strategies and therapeutics, novel diagnostics, procedures, devices; and the ability to predict in humans the efficacy of those next-generation therapeutics, procedures, and devices.
Each Precigen Exemplar facility is accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC). Our employees are active members of the American Association of Laboratory Animal Science, which is dedicated to the humane care and treatment of laboratory animals, and we also comply with the letter and spirit of the Animal Welfare Act.
Precigen Exemplar is a subsidiary of Precigen.
Our ApproachLearn More
Precigen Exemplar is advancing a broad pipeline of proprietary genetically engineered ExeGen® MiniSwine models that are invaluable for disease mechanism discovery and preclinical efficacy testing.
Miniature Swine for the Biomedical Market
The Yucatan MiniSwine is the accepted standard and ideal model for the biomedical and medical device fields. MiniSwine research models are designed to provide improved predictive power to the preclinical stages of therapeutic development.
Precigen Exemplar is a leader in providing MiniSwine for research in human diseases. Our models have a wide range of applications ultimately enabling discovery.
Learn more about our models and how they’re being applied to medical research.
We are committed to the humane use and care of each research animal. Our first priority is animal welfare, and we have rigorous standards to ensure that we meet or exceed all requirements for care though a robust program of care and established veterinary protocols. Each one of our facilities is PHS assured, FDA compliant and USDA approved.
We believe our work will enable discovery of life saving drugs, devices and therapies and every employee of Precigen Exemplar believes each animal deserves the greatest respect and care – and that’s exactly what we deliver every day.
Our Platform Advantages
Benefits of Miniature Swine Models
Our ExeGen® Yucatan miniature pig models offer a more accurate and effective testing platform for new treatments than traditional mouse models.
Advantages of Miniature Swine Over Traditional Models:
- Human-like disease phenotypes on accelerated timelines
- Human-like size useful for device and imaging work
- Anatomically similar to humans (e.g., similar structure of cardiovascular systems)
- Improved translational value to human clinical trials
Challenges of Medical Product Development
The process to develop successful treatments can be costly and for rare disease states, limited patient populations make predictive efficacy much more difficult.
MiniSwine models aim to address these challenges and improve the outcomes, enabling significant cost savings in development and the ability to bring medications to market faster.
Precigen Exemplar is providing miniature swine models to enable research in human diseases.
Precigen Exemplar Pipeline
|Model||Indication||Gene Targeting||Founders||Characterization||Available in Portfolio|
|ExeGen LDLR -/- & +/-||Heart Disease|
|ExeGen CFTR-/-||Cystic Fibrosis|
|ExeGen CFTRF508del/F508del||Cystic Fibrosis|
|ExeGen SCN5A+/E558X||Cardiac Arrhythmia|
|ExeGen TP53+/R167H, R167/R167H||Cancer|
|ExeGen TP53+/R167H & KRAS+G12D||Cancer|
|ExeGen MYH7+/R403Q||Hypertrophic Cardiomyopathy|
|ExeGen NF1+/ex42del||Nervous System|
|ExeGen PKD1+/-||Renal Disease|
|ExeGen SCDhHBA/hHBA/hHBG-hHBBS/ hHBG-hHBBS||Blood Disorders|